Association of bronchopulmonary sequestration with expression of the homeobox protein Hoxb-5.
Publication/Presentation Date
12-1-2000
Abstract
Bronchopulmonary sequestration (BPS) is caused by the abnormal development of an accessory lung diverticulum from the foregut very early in embryogenesis. The developmental abnormalities seen with BPS suggest that this anomaly is caused by abnormal expression of homeobox genes, which control axial identity and organ-specific patterning during embryogenesis. The authors previously have shown that the homeobox gene Hoxb-5 is necessary for normal airway branching during lung development. The authors now report that BPS is associated with aberrant developmental expression of Hoxb-5 protein, suggesting that this Hox gene is involved in the development of BPS.
Volume
35
Issue
12
First Page
1817
Last Page
1819
ISSN
0022-3468
Published In/Presented At
Volpe, M. V., Archavachotikul, K., Bhan, I., Lessin, M. S., & Nielsen, H. C. (2000). Association of bronchopulmonary sequestration with expression of the homeobox protein Hoxb-5. Journal of pediatric surgery, 35(12), 1817–1819. https://doi.org/10.1053/jpsu.2000.19266
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
11101743
Department(s)
Department of Pediatrics, Department of Surgery
Document Type
Article