Expression of CD5 on hematogones in a 7-year-old girl with Shwachman-Diamond syndrome.
We report increased numbers of hematogones in a 7-year-old girl with pancytopenia due to Shwachman-Diamond syndrome. Her hematogones expressed the T-cell marker CD5 as well as CD19, CD10, and CD20, and terminal deoxynucleotidyl transferase and HLA-DR. These findings suggest that hematogones are precursors of both CD5-positive B cells and CD5-negative B cells. Thus CD5-positive B cells in bone marrow may be derived from bone marrow stem cells, and not from the residual fetal B cells of yolk sac/liver origin. The finding of CD5 expression on hematogones also raises the possibility that neoplastic B cells of chronic lymphocytic leukemia, which characteristically co-express CD5 and CD19, may be derived from CD5-positive B-cell precursors in bone marrow and not from mature B cells in lymph nodes.
Published In/Presented At
Jelic, T. M., Raj, A. B., Jin, B., Kurczynski, E. M., Tolaymat, N., & Chang, H. H. (2001). Expression of CD5 on hematogones in a 7-year-old girl with Shwachman-Diamond syndrome. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 4(5), 505–511. https://doi.org/10.1007/s10024001-0083-5
Medicine and Health Sciences | Pediatrics
Department of Pediatrics