Hepatic dysfunction as the presenting feature of acute lymphoblastic leukemia.
Publication/Presentation Date
2-1-2001
Abstract
PURPOSE: Hepatic dysfunction is a rare presentation of leukemia in children. Because most chemotherapy agents are metabolized by the liver, this complication may have major adverse consequences and effective treatment could be compromised.
PATIENTS AND METHODS: The MEDLINE database and current management guidelines from the United States Pediatric Cooperative Cancer Groups were reviewed and analyzed. Data from two institutional cases are described.
RESULTS: Although previous literature is not informative, our experience suggests that children with leukemia and moderate hepatic dysfunction may tolerate aggressive chemotherapy.
CONCLUSION: Current protocol guidelines for dose modification for liver disease may be overly stringent and modification may be beneficial.
Volume
23
Issue
2
First Page
117
Last Page
121
ISSN
1077-4114
Published In/Presented At
Kelleher, J. F., Monteleone, P. M., Steele, D. A., Gang, D. L., & Angelides, A. G. (2001). Hepatic dysfunction as the presenting feature of acute lymphoblastic leukemia. Journal of pediatric hematology/oncology, 23(2), 117–121. https://doi.org/10.1097/00043426-200102000-00010
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
11216703
Department(s)
Department of Pediatrics
Document Type
Article