Differential effects of cytolytic T cell subsets on intracellular infection.

Publication/Presentation Date

6-13-1997

Abstract

In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4(-)CD8(-) (double-negative) T cells and CD8(+) T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4(-)CD8(-) T cells was mediated by Fas-FasL interaction and had no effect on the viability of the mycobacteria. The CD8(+) T cells lysed infected macrophages by a Fas-independent, granule-dependent mechanism that resulted in killing of bacteria. These data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.

Volume

276

Issue

5319

First Page

1684

Last Page

1687

ISSN

0036-8075

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

9180075

Department(s)

Department of Pediatrics

Document Type

Article

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