Differential effects of cytolytic T cell subsets on intracellular infection.
Publication/Presentation Date
6-13-1997
Abstract
In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4(-)CD8(-) (double-negative) T cells and CD8(+) T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4(-)CD8(-) T cells was mediated by Fas-FasL interaction and had no effect on the viability of the mycobacteria. The CD8(+) T cells lysed infected macrophages by a Fas-independent, granule-dependent mechanism that resulted in killing of bacteria. These data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.
Volume
276
Issue
5319
First Page
1684
Last Page
1687
ISSN
0036-8075
Published In/Presented At
Stenger, S., Mazzaccaro, R. J., Uyemura, K., Cho, S., Barnes, P. F., Rosat, J. P., Sette, A., Brenner, M. B., Porcelli, S. A., Bloom, B. R., & Modlin, R. L. (1997). Differential effects of cytolytic T cell subsets on intracellular infection. Science (New York, N.Y.), 276(5319), 1684–1687. https://doi.org/10.1126/science.276.5319.1684
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
9180075
Department(s)
Department of Pediatrics
Document Type
Article