Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.
Publication/Presentation Date
10-1-1993
Abstract
Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most reports have been in adult patients, with rare reports in the pediatric population. We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21. As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and, thus warrant close evaluation while on such medications.
Volume
14
Issue
4
First Page
227
Last Page
229
ISSN
0172-0643
Published In/Presented At
Gleason, M. M., Roloff, J. S., Cyran, S. E., Weber, H. S., Baylen, B. G., & Myers, J. L. (1993). Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21. Pediatric cardiology, 14(4), 227–229. https://doi.org/10.1007/BF00795376
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
8255797
Department(s)
Department of Pediatrics
Document Type
Article