Basic elements of gene mapping and identification.
Publication/Presentation Date
5-1-1997
Abstract
The Human Genome Project has vastly facilitated the localization, identification, and characterization of disease-related genes by means of positional cloning. Application of this technique has elucidated the pathophysiology of several inheritable cardiovascular disorders and will ultimately change the clinical evaluation of and approach to these diseases. Over the next several years, efforts aimed at gene identification, DNA sequencing, correlation of genetic and physical maps, and manipulation of large segments of DNA will lead to identification of numerous candidate genes for positional analysis and will provide ample opportunity to identify the genetic abnormalities in other cardiovascular disorders. Because of the importance and clinical implications of these advances, a conceptual understanding of this methodology is essential to the practicing clinician.
Volume
12
Issue
3
First Page
288
Last Page
294
ISSN
0268-4705
Published In/Presented At
Consevage, M., & Cyran, S. (1997). Basic elements of gene mapping and identification. Current opinion in cardiology, 12(3), 288–294. https://doi.org/10.1097/00001573-199705000-00010
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
9243086
Department(s)
Department of Pediatrics
Document Type
Article